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2010 Jan-Mar; Vol 1, No 1:e9 |
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e9 |
Hereditary Angioedema: Three Cases Report, Members of the Same Family J Oral Maxillofac Res 2010 (Jan-Mar);1(1):e9 doi:10.5037/jomr.2010.1109 |
Hereditary Angioedema: Three Cases Report, Members of the Same Family
1Department of Dentistry, General Hospital of Volos, Volos, Greece
2Department of Internal Medicine, General Hospital "AHEPA", School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
3Department of Otorinolaryngology, General Hospital of Volos, Volos, Greece
4Department of Oral Medicine and Maxillofacial Pathology, School of Dentistry, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Corresponding author:
93 Tsimiski
GR-54622, Thessaloniki
Greece
Phone: 0030 2310 236207
Fax: 00302310 236207
E-mail: apismat@yahoo.gr
ABSTRACT
Background: This current clinical case report highlights three cases of Hereditary angioedema (HAE) patients who are all members of the same family (father and his two daughters). The father has C1–INH deficiency, while his daughters have low C1–INH levels: the first possesses only 10% function and the second has low C1–INH level with 0% function. Of note, the second daughter was discovered to have HAE at the age of 2, thus making her the youngest known HAE case report in the English literature.
Methods: Assess the efficacy of administration of C1-INH before dental operation as regards the prevention of HAE episode, when total or partial C1-INH deficiency exists.
Results: Acute angioedema leading to laryngeal oedema is a possibly fatal complication for HAE patients undergoing dental procedures. Use of both short-term and long-term HAE prophylaxis prior to dental operations might be life saving for those patients.
Conclusions: Prevention and early recognition of potential laryngeal oedema that can occur as a complication of dental procedures may be lifesaving for HAE patients.
J Oral Maxillofac Res 2010 (Jan-Mar);1(1):e9
doi:10.5037/jomr.2010.1109
Accepted for publication: 29 December 2009
Keywords: hereditary angioedema; laryngeal edema; oral surgical procedure; operative dentistry; tooth extraction.
To cite this article: Hereditary Angioedema: Three Cases Report, Members of the Same Family J Oral Maxillofac Res 2010 (Jan-Mar);1(1):e9 |
Received: 9 December 2009 | Accepted: 29 December 2009 | Published: 1 April 2010
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2010.