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2011 Jan-Mar; Vol 2, No 1:e2 |
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The Use of Platelet Rich Plasma, Bone Morphogenetic Protein-2 and Different Scaffolds in Oral and Maxillofacial Surgery - Literature Review in Comparison with Own Clinical Experience J Oral Maxillofac Res 2011 (Jan-Mar);2(1):e2 doi:10.5037/jomr.2011.2102 |
The Use of Platelet Rich Plasma, Bone Morphogenetic Protein-2 and Different Scaffolds in Oral and Maxillofacial Surgery - Literature Review in Comparison with Own Clinical Experience
1Institute Indente – Institute of Innovative Oral Surgery and Medicine, Centre for Tissue Engineering, Hannover, Germany.
Corresponding author:
Institute Indente – Institute of Innovative Oral Surgery and Medicine
Centre for Tissue Engineering, Hannover
Germany
Phone: +49 511 850 6232
Fax: +49 511 281757
E-mail: k-h.schuckert@indente.de
ABSTRACT
Objectives: The purpose of this article was to review and critically assess the use of platelet rich plasma, recombinant human bone morphogenetic protein-2 and different scaffolds (i.e. tricalciumphosphate, polycaprolactone, demineralized bone matrix and anorganic bovine bone mineral) in oral and maxillofacial surgery comparing the relevant literature and own clinical experience.
Material and Methods: A literature review was conducted using MEDLINE, MEDPILOT and COCHRANE DATABASE OF SYSTEMATIC REVIEWS. It concentrated on manuscripts and overviews published in the last five years (2006-2010). The key terms employed were platelet rich plasma, bone morphogenetic proteins and their combinations with the above mentioned scaffolds. The results of clinical studies and animal trials were especially emphasized. The statements from the literature were compared with authors’ own clinical data.
Results: New publications and overviews demonstrate the advantages of platelet rich plasma in bone regeneration. The results from the literature review were discussed and compared with the publications detailing authors’ own experiences.
Conclusions: A favourable outcome concerning newly grown bone was achieved combining platelet rich plasma in addition to optimal matrices with or without recombinant human bone morphogenetic protein-2, depending on the clinical case. As a consequence, the paradigm shift from transplantation of autogenous bone to bone tissue engineering appears promising.
J Oral Maxillofac Res 2011 (Jan-Mar);2(1):e2
doi:10.5037/jomr.2011.2102
Accepted for publication: 18 January 2011
Keywords: platelet-rich plasma; growth factors; bone morphogenetic protein 2; tissue engineering; bone regeneration; bone replacement materials.
To cite this article: The Use of Platelet Rich Plasma, Bone Morphogenetic Protein-2 and Different Scaffolds in Oral and Maxillofacial Surgery - Literature Review in Comparison with Own Clinical Experience. J Oral Maxillofac Res 2011;2(1):e2 URL: http://www.ejomr.org/JOMR/archives/2011/1/e2/v2n1e2ht.htm |
Received: 29 November 2010 | Accepted: 18 January 2011 | Published: 1 April 2011
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2011.