« Prev |
2017 Jan-Mar; Vol 8, No 1:e1 |
Next » |
e1 |
Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review J Oral Maxillofac Res 2017;8(1):e1 doi:10.5037/jomr.2017.8101 |
Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review
1Department of Oral and Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Corresponding Author:
Bar Ilan 17-4, Bat Yam, 5958135
Israel
Phone: +972 524622975
Fax: 03-5533061
E-mail: natali0230@walla.com
ABSTRACT
Objectives: The purpose of this article is to systematically review the methods of mobilization, isolation and characterization of stem cells from peripheral blood and to discuss their potential therapeutic applications for bone tissue regeneration.
Material and Methods: An electronic literature search was performed through MEDLINE (PubMed) electronic database. The search was restricted to English language articles published during the last 10 years, from January 2006 to November 2016.
Results: In total, 37 literature sources were reviewed, and 11 of the most relevant articles that are suitable to the criteria were selected. Articles were analysed with data on animals and humans for mobilization, isolation and characterization of stem cells from peripheral blood. From the examination of selected articles, the mobilization materials, side effects, alternatives and factors affecting the extracted amount of mesenchymal stem cells (MSC) from mobilized peripheral blood of healthy individuals, as well as characterization of mobilized MSC were reviewed in this article.
Conclusions: Bone tissue engineering is a potential alternative strategy in bone regeneration and bone defect repair, however, insufficiency data display in the literature on potential therapeutic applications of peripheral blood stem cells for bone tissue regeneration.
J Oral Maxillofac Res 2017;8(1):e1
doi: 10.5037/jomr.2017.8101
Accepted for publication: 31 March 2017
Keywords: blood; bone regeneration; cell isolation; hematopoietic stem cell mobilization; peripheral blood stem cells.
To cite this article: Yosupov N, Haimov H, Juodzbalys G. Mobilization, Isolation and Characterization of Stem Cells from Peripheral Blood: a Systematic Review J Oral Maxillofac Res 2017;8(1):e1 URL: http://www.ejomr.org/JOMR/archives/2017/1/e1/v8n1e1.pdf |
Received: 8 March 2017 | Accepted: 20 March 2017 | Published: 31 March 2017
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2017.