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Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model J Oral Maxillofac Res 2017;8(4):e3 doi:10.5037/jomr.2017.8403 Abstract | HTML | PDF | XML |
Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model
1Department of Radiology, Nationwide Children’s Hospital, Columbus, Ohio, USA.
Corresponding Author:
Radiology Department, Nationwide Children’s Hospital
700 Children’s Drive, Columbus, OH 43205
USA
Phone: +1 614 722 2289
Fax: +1 614 722 2332
E-mail: James.Murakami@nationwidechildrens.org
ABSTRACT
Objectives: Sialorrhea is a common health and psychosocial problem for children with neuromuscular dysfunction secondary to a variety of disorders such as cerebral palsy. Current accepted treatments include the injection of botulinum toxin into the submandibular glands for temporary symptom relief. The purpose of this study is to demonstrate the feasibility of percutaneous ethanol injection for longer lasting salivary gland ablation in an animal model.
Material and Methods: Twenty rats were used in this study. In each rat, 98% ethanol was injected into the right submandibular gland under ultrasound guidance. No intervention was performed on the left gland, which served as the control. Ten rats were sacrificed and glands evaluated at three weeks, with the remaining 10 rats sacrificed and evaluated at three months. Unpaired, 1-tailed T-tests were used to analyse the data.
Results: Ethanol injections induced a significant and sustained reduction in salivary gland size. Treated glands were 41% smaller by mass than untreated controls in the 10 rats sacrificed at three weeks (P < 0.001). Treated glands were 43% smaller by mass than untreated controls in the 10 rats sacrificed at three months (P < 0.001). Qualitative histologic analysis demonstrated extensive parenchymal damage, inflammation, and fibrosis at both three week and three month time points.
Conclusions: Using a rat model, we demonstrated dramatic and sustained submandibular gland damage after percutaneous injection of ethanol.
J Oral Maxillofac Res 2017;8(4):e3
doi: 10.5037/jomr.2017.8403
Accepted for publication: 29 December 2017
Keywords: ethanol; injections; rat; sialorrhea; submandibular gland.
To cite this article: Percutaneous Salivary Gland Ablation using Ethanol in a Rat Model J Oral Maxillofac Res 2017;8(4):e3 URL: http://www.ejomr.org/JOMR/archives/2017/4/e3/v8n4e3ht.htm |
Received: 11 November 2017 | Accepted: 29 December 2017 | Published: 31 December 2017
Copyright: © The Author(s). Published by JOMR under CC BY-NC-ND 3.0 licence, 2017.